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Chondromodulin-I and tenomodulin: the negative control of angiogenesis in connective tissue.
The negative regulation of angiogenesis may provide a promising therapeutic target for a number of lifestyle-related diseases, as the switch to an angiogenic phenotype in many tissues represents a critical step during the progression of such disorders. Cartilage is avascular and shows resistance to vascular invasion from the surrounding well-vascularized mesenchyme. Using guanidine extracts of ...
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Chinese Herbal Medicine (CHM) plays a significant role in breast cancer treatment. We conduct the study to ascertain the relative molecular targets of effective Chinese herbs in treating stage IV breast cancer.Survival benefit of CHM was verified by Kaplan-Meier method and Cox regression analysis. A bivariate correlation analysis was used to find and establish the effect of herbs in complex CHM...
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To evaluate the effect of Chinese herbal medicine (CHM) on albuminuria levels in patients with diabetic nephropathy (DN), we performed comprehensive searches on Medline database, Cochrane Library, CNKI database, CBM database, Wanfang database, and VIP database up to December 2012. A total of 29 trials including 2440 participants with DN met the selection criteria. CHM was tested to be more effe...
متن کاملChondromodulin I is dispensable during enchondral ossification and eye development.
Chondromodulin I (chm-I), a type II transmembrane protein, is highly expressed in the avascular zones of cartilage but is downregulated in the hypertrophic region, which is invaded by blood vessels during enchondral ossification. In vitro and in vivo assays with the purified protein have shown chondrocyte-modulating and angiogenesis-inhibiting functions. To investigate chm-I function in vivo, w...
متن کاملمقایسه ابزارهای توپوگرافی و فرمولهای محاسبه قدرت قرنیه با روش تاریخچه بالینی و روش گالیله به دنبال جراحی کراتکتومی فوتورفرکتیو
هدف: اندازه‌گیری قدرت قرنیه با استفاده از توپوگرافی، ارب‌اسکن، کراتومتری دستی، قرنیه و دو فرمول AdjACCP و AdjEFFRP با TCP گالیله و CHM به عنوان مرجع و مقایسه میزان انطباق و همبستگی این دستگاه‌ها و فرمولها در تشخیص قدرت قرنیه در بیماران به دنبال جراحی کراتکتومی فوتورفرکتیو. روش پژوهش: این مطالعه بر روی 66 چشم از 33 بیمار کاندید جراحی رفرکتیو انجام شد. قدرت مرکزی قرنیه بیماران با استفاده ازک...
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